Formulation, optimization and evaluation of self nanoemulsifying drug delivery system of paliperidone

Paliperidone is a BCS-II drug. It means paliperidone poorly water soluble and hence shows problem in absorption as well permeation through GIT which together contributes for its lower oral bioavailability. drug, oil oleic acid, surfactant labrasol co labrafil m 1944 were taken formulation done. From the emulsification time study concentration of Smix increases decreases. Further I found that F3 has lowest time. dissolution it was observed Q30 above 85% obtained F6 93.75 & 91.25. This can be due to higher present since mean cumulative % drug release at 30min (Q30) highest selected optimized formulation. As DSC thecrystalline property lost becomes amorphous. In FT-IR there no significance sifting characteristic peak. Hence incompatibility between excipient.